There is a huge variety to what you might see from run to run and region to region.
5 dungeon regions, 26 floors, over 100 room types, and trillions of possible floor layouts. Shattered Pixel Dungeon 9 optional challenges and over 100 achievements for completionists. Over 250 items including equipment, consumables, and items crafted via alchemy. ShatteredPD's dungeon is procedurally generated with random layouts, room types, items, traps, and enemies.